It was a part of the Bayley Seton campus of Richmond University Medical Center but is permanently closed.

Bayley Seton is located on a 20-acre (81,000 m2), 12-building site in the Clifton and Stapleton areas of the North Shore of the New York City Borough of Staten Island.

On May 6, 1857, the neighboring New York Marine Hospital (also the "Quarantine") in Tompkinsville, about 1 mile (1.6 km) north along the shore, was attacked by a local mob, fearful of the mostly immigrant detainees.

In 1887, 28-year-old officer Joseph J. Kinyoun established a single-room Laboratory of Hygiene for Bacteriological Investigation on the top floor of the Marine Hospital, where it remained until 1891.

[7] In 1902, the United States Congress passed legislation to fund the laboratory and move it to Washington where, as a result of the 1930 Ransdell Act, it became the National Institutes of Health.

[8] Military installations at Fort Wadsworth, Fort Hamilton (just across the narrows in Brooklyn), the Staten Island Homeport, Miller Field Air Station, as well as air, naval and Coast Guard installations built during the Second World War assured a large military and veteran population for the hospital.

In 1980, President Ronald Reagan announced plans to close or sell all such hospitals, and despite local protest, Staten Island Public Health Service Hospital was sold to the Sisters of Charity of New York, a Catholic medical and social services system.

In 2000, Sisters of Charity turned over Bayley Seton (along with their main Staten Island hospital) to Saint Vincent's Catholic Medical Center, which already included the Sisters' Manhattan and Westchester County hospitals, to create Saint Vincent's Catholic Medical Centers New York.

[11] Facing financial difficulties almost immediately, Bayley saw around half its services closed, including its emergency room, pharmacy, surgery, and most medical clinics.

The Salvation Army had purchased a seven-acre portion of the campus with the intention of redeveloping the site into senior housing or a community center.