[1] Port Phillip contains a number of varied and substantial retail, entertainment and leisure precincts.

A number of significant employment areas lie within Port Phillip, including part of the St Kilda Road business district and industrial, warehousing and manufacturing districts in South Melbourne and Port Melbourne.

[citation needed] The city has experienced a significant amount of residential development in the 1990s, particularly in areas close to the foreshore.

[citation needed] Port Phillip is well served by public transport with a substantial tram network, the St Kilda and Port Melbourne tram lines and two stations on the Sandringham railway line, in addition to bus services.

In 2020 ANAM was given a long lease to South Melbourne Town Hall and council staff there and a few community groups vacated the building.