Clair-Mel City (Clair Mel) is an unincorporated community in Hillsborough County, Florida, United States.

On April 10, 1978, a three-way traffic collision in Clair-Mel City killed the driver of a tank truck and injured two other motorists.

A cloud of ammonia gas escaped from the overturned truck, forcing several hundred people to evacuate.

[2] Clair Mel City is located at 27.93 North, 82.38 West (27.933359, -82.37821),[3] or approximately 7 miles (11 km) east-southeast of Tampa.

Clair Mel boundaries include Palm River to the west, Tampa city limits to the north, the Lee Roy Selmon Expressway to the east, and Progress Village to the south.