Clarence High School, also known as Clarence Central High School or, formerly, Clarence Senior High School, is a public high school located in Clarence, Erie County, New York, United States.

Established in 1949 by the New York State Board of Regents.

The district includes six schools in the Clarence area, east of Buffalo, New York.

In 2006 and 2007, Clarence stayed in the first spot in the Business First School rankings.

[4] In 2009, Clarence was ranked 4th out of 131 Western New York high schools.