Clarke Lewis (November 8, 1840 – March 13, 1896) was an American educator, Civil War veteran, and politician who served two terms as a United States representative from Mississippi from 1889 to 1893.

He moved with his mother to Noxubee County, Mississippi in 1844 where he attended the district schools and Somerville Institute and also engaged in teaching for several years.

Lewis entered the Confederate Army in February 1861 and served until the close of the American Civil War.

He was also employed as a clerk in a store in 1866 and 1867 and engaged in mercantile and agricultural pursuits 1867–1879.

Lewis was a member of the Mississippi House of Representatives in 1878.