Other major cities within the district include Bay St. Louis, Laurel, and Pascagoula.

[4] The perimeter of the current Fourth District extends across the ninety-mile coastal southern edge of Mississippi from the Louisiana border to the Alabama border, following the Alabama state line north along the eastern border of the state to a point due east of Quitman in Clarke County where it is bounded by the 3rd District and then moves in an irregular fashion south of Quitman until it reaches the county line with Wayne County, and then follows the northern and western borders to wholly contain Jones, Forrest, Lamar, and Marion counties until it reaches the Louisiana state line, ultimately bounded by the Pearl River winding to its outlet in Lake Borgne.

US Highway 84 enters the state near Waynesboro and is four-laned statewide, passing through Laurel, Brookhaven and Natchez.

Long after this area turned solidly Republican at the federal level, conservative Democrats like longtime congressman Gene Taylor still held a number of local offices.

This came to pass in 2010, when then-state representative Palazzo narrowly defeated Taylor in that year's massive Republican wave.

Palazzo's win touched off a wave of Republican victories down ballot, and today there are almost no elected Democrats left above the county level.

Since 2013 the entire counties of Hancock, Harrison, Jackson, Pearl River, Stone, George, Marion, Lamar, Forrest, Perry, Greene, Jones, and Wayne, along with the southeastern part of Clarke are counted in this district.

[6] Wiley Pope Harris(Monticello) Singleton(Canton) Frederick G. Barry(West Point) Andrew F. Fox(West Point) Fourth District incumbent Gene Taylor (D) was re-elected, gathering 80% of the Fourth District's vote.