Clarksville is a town in Mecklenburg county in the U.S. state of Virginia, near the southern border of the commonwealth.

Located along the Roanoke River, these lands were for centuries the home to the Occaneechi Native Americans.

The Eno-Occoneechee tribe are directly descendants of the original Occoneechees and currently reside in nearby Vance County, North Carolina.

A plank road was built from Clarksville to Petersburg (distance of 80 miles (130 km) for overland transport.

In years to follow, the Roanoke Valley Railroad was built from Clarksville to Manson, North Carolina.

In 1860, R. H. Moss and Brothers Factory in Clarksville was producing more manufactured tobacco than any other establishment in Virginia or the Carolinas.

To date, Clarksville proudly claims the title of the oldest continuous tobacco market in the world.

The Clarksville Historic District, Cedar Grove, Prestwould, Clark Royster House, Sunnyside, Patrick Robert Sydnor Log Cabin, and Judge Henry Wood, Jr. House are listed on the National Register of Historic Places.

The climate in this area is characterized by hot, humid summers and generally mild to cool winters.