Currently headquartered at Clatterbridge Health Park, Bebington, Wirral, the Trust operates an extensive network of services across Cheshire and Merseyside which includes their three sites in Liverpool, Wirral and Aintree, as well as clinics in hospitals across the region, and its team of specialist nurses who treat patients while they're at home or work.

This hospital moved to a new site and became The Radium Institute and by 1901 was one of the two major radiotherapy centres in the North West of England.

The intention was to achieve VAT benefits, as well as pay bill savings, by recruiting new staff on less expensive non-NHS contracts.

[1] In this review; its authors, Professor Mark Baker and Mr Roger Cannon, recommended that an inpatient cancer treatment facility be built in Liverpool.

The Clatterbridge Cancer Centre Foundation Trust announced in 2011 that this recommendation was being actioned,[18] and would take advantage of separate, but concurrent, plans for the redevelopment of the Royal Liverpool University Hospital.

[10] Approval to move forward with the plan for the new cancer hospital on West Derby Street, Liverpool was given by the eight local authorities in December 2014.

[23] Specialist chemotherapy nurses from The Clatterbridge Cancer Centre currently visit patients at home in certain areas of Merseyside and Cheshire to deliver trastuzumab (Herceptin).

The trust provides some nursing staff to the Countess of Chester Hospital, allowing breast, bowel, lung and prostate cancer patients to be given chemotherapy on Haematology & Oncology unit.

[26][27] The Linda McCartney Centre is located in a converted, former nursing college at the Royal Liverpool University Hospital.

[29] The trust opened a unit dedicated to chemotherapy for gynaecological cancers at the Liverpool Women's Hospital, in February 2011.

[30] Treating breast, bowel, urology and lung cancers, The Marina Dalglish Centre was opened in 2007, having been converted from an old special care baby unit.

Following a £1.3 million renovation,[32] the centre runs a nurse-led chemotherapy delivery service from Southport Hospital's Medical Day Unit, for bowel, breast and lung cancer patients.