Claudio Colica began his career together with his brother Fabrizio, creating the comedy duo Le Coliche ("The colics") and publishing short videos on social media about various everyday topics, pop culture and life in Rome.
[3][4] In 2016, he was part of the cast of the TV series Vegan Chronicles, and the following year, he appeared in the short film Grosso guaio a Roma Sud.
[6][7] In 2021, the duo published their first autobiographical book, Come il mal di pancia, with illustrations by comic artist Giacomo Bevilacqua.
[8][9] In 2022, he landed his first leading role, alongside Christian De Sica, Angela Finocchiaro, and Dharma Mangia Woods, in the Netflix comedy The Price of Family, where he played Emilio Delle Fave.
[10] Subsequently, he had supporting roles in the films Io e mio fratello by Luca Lucini and Mascarpone: The Rainbow Cake by Alessandro Guida.