Fabrizio Colica began his career together with his brother Claudio, creating the comedy duo Le Coliche ("The colics") and publishing short videos on social media about various everyday topics, pop culture and life in Rome.
[6] Subsequently, he had supporting roles in the films Rainbow: A Private Affair by the Taviani brothers in 2017, and Good Gals by Michela Andreozzi in 2019.
[7] In 2018, he took part with his brother Claudio at the Rai 2 reality game show Pechino Express; after his brother's injury, he continued the competition in pairs with Tommy Kuti, ultimately finishing in second place.
[8][9] In 2021, the duo published their first autobiographical book, Come il mal di pancia, with illustrations by comic artist Giacomo Bevilacqua.
[10][11] In 2024, Colica starred in the Amazon original film Still Fabulous and in Michela Giraud's directorial debut Flaminia.