Clavam

Clavam tablets may be effective for short-term treatment of bronchitis, cystitis, sinusitis, otitis media, or skin infections.

[5][6] Clavams are commonly used in conjunction with other antibiotics such as amoxicillin to produce a broader therapeutic effect.

5S clavams do not have an inhibitory effect on β-lactamase, but are involved in methionine biosynthesis inhibition, making them bacteriostatic agents.

[9] Additionally, 5S Clavams may have inhibitory effects on RNA synthesis, which is a common property of anti-fungal medications.

CcaR is important for the expression of polycistronic transcripts, which are early genes for clavulanic acid biosynthesis.