Clear-cell renal-cell carcinoma (CCRCC) is a type of renal-cell carcinoma.
Several frequently mutated genes were discovered in CCRCC: VHL, KDM6A/UTX, SETD2, KDM5C/JARID1C and MLL2.
[citation needed] CCRCC is derived from the proximal convoluted tubule.
[citation needed] Generally, the cells have a clear cytoplasm, are surrounded by a distinct cell membrane and contain round and uniform nuclei.
[citation needed] Microscopically, CCRCCs are graded by the ISUP/WHO as follows:[1][2]