Clemson Area Transit, a zero-fare bus line known locally as CAT or the "CAT Bus", is the most frequently used transit system in South Carolina.

The fare-free system is made possible by federal grants and matching funds from the city and University.

Utilizing multiple routes and lines, CAT Buses help transport citizens and students from campus or downtown to surrounding neighborhoods and apartment complexes, and move travelers from the Clemson area to surrounding communities.

The service is jointly operated by the City of Clemson, Clemson University, the Town of Pendleton, City of Seneca, Southern Wesleyan University, and the Town of Central CAT buses are characterized by purple and orange paint schemes.

Buses operated in Seneca have a dark blue and gold color scheme.