The station sits on the corner of Calhoun Memorial Highway and College Avenue in the heart of downtown Clemson.

Edwards, then Clemson University president, convinced D.W. Brosnan, president of the Southern at the time, to prefer Clemson over Seneca as the main station for the area.

On January 31, 1979, the Southern discontinued passenger service, turning operations of the Crescent over to Amtrak.

An Amtrak Thruway bus transferred Clemson passengers to Greenville.

[2] Amtrak's Crescent resumed normal service at Clemson station on August 1, 2019.