The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[2][3] throughout Cleveland and the wider northern Ohio region.

[7] While the new facility will join children's primary and specialty outpatient care in one location, inpatients would still be housed at the M Building.

[10][11] In 2019 it was announced that Akron Children's Hospital and the Cleveland Clinic would be expanding the pediatric and adult congenital heart program that was started 2014.

[13] The hospital has an American Academy of Pediatrics verified level III neonatal intensive care unit that has a capacity of 17 bassinets.

[22][23] The hospital provides comprehensive pediatric rehabilitative services for children with disabilities caused by trauma, birth defects, brain and spinal-cord injury, respiratory, orthopedic and developmental disorders.