Clifton Powell (born March 16, 1956) is an American actor who primarily plays supporting roles in films, such as in Ray (2004), for which he received an NAACP Image Award for Outstanding Supporting Actor in a Motion Picture nomination.

His credits include Menace II Society (1993), Dead Presidents (1995), Why Do Fools Fall in Love (1998), Rush Hour (1998), Next Friday (2000), and its 2002 sequel, Friday After Next, Woman Thou Art Loosed (2004), and Ray (2004).

On television, Powell had the recurring roles on Roc, South Central, and Army Wives, and well as guest-starred on In the Heat of the Night, Murder, She Wrote, NYPD Blue, CSI: Crime Scene Investigation, and House.

In 2016, Powell was cast as main antagonist in the Bounce TV first prime time soap opera, Saints & Sinners opposite Vanessa Bell Calloway and Gloria Reuben.

Powell is also known for his voice acting role as Big Smoke in the 2004 video game Grand Theft Auto: San Andreas.