It was designated wilderness in 1985 and is managed by the Cumberland Ranger District of the Daniel Boone National Forest.

[2] Located within the Red River Gorge Geological Area, Clifty Wilderness is a rugged area characterized by high cliffs, steep valleys, numerous sandstone arches, rock shelters, and boulder-strewn creeks.

[3] The Wilderness contains at least 15 sensitive, rare or endangered plant species among more than 750 different flowering plants and 170 species of moss.

[4] The Wild and Scenic Red River bisects Clifty Wilderness.

9.1 miles (15 km) of the river are designated "wild" and 10.3 miles (17 km) are designated "recreational.