[1] The only known localities of Clione okhotensis are in the southern Sea of Okhotsk[2] and the Kuril–Kamchatka Trench area[3] in the western Pacific Ocean.

Its distribution overlaps with those of C. limacina and C. elegantissima, two separate species of the same genus found in the North Pacific.

[2] Clione okhotensis inhabits cold, shallow waters of the Sea of Okhotsk.

[5] Although its buccal cones are unused in predation, they are still visibly retracted and extended during attempt behavior.

[6] Though the direct effects of global warming on Clione okhotensis have yet to be evaluated, its populations could be negatively impacted by a decline in the populations of its primary prey, Limacina helicina, which is extremely vulnerable to ocean acidification due to its aragonitic (calcium carbonate) shell.