Clyo is an unincorporated community in Effingham County, Georgia, United States.

The community is located along Georgia State Route 119, 8.1 miles (13.0 km) north-northeast of Springfield.

[2][3] "Tuckasee King", a former variant name of Clyo, served as Effingham County seat from 1784 until 1787.

[5] The community was named after Clio, the muse of history in Greek mythology.

This Effingham County, Georgia state location article is a stub.