Cobamide is a naturally occurring chemical compound containing cobalt in the corrinoid family of macrocyclic complexes.

Cobamide works as a coenzyme with some enzymes in bacteria.

The cobalt atom may have a transferable methyl group attached.

It is used for example in 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase.

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