Cobb syndrome

Cobb syndrome is a rare congenital disorder characterized by visible skin lesions and spinal angiomas or arteriovenous malformations (AVMs).

[1] The skin lesions of Cobb syndrome typically are present as port wine stains or angiomas, but reports exist of angiokeratomas,[2] angiolipomas, and lymphangioma circumscriptum.

[3] The intraspinal lesions may be angiomas or AVMs and occur at levels of the spinal cord corresponding to the affected skin dermatomes.

Patients typically experience the sudden onset of pain, numbness, or weakness in their extremities as children or young adults.

A possible complication if treatment is delayed is Foix-Alajouanine syndrome[6] or subacute necrotic myelopathy due to thrombosis in the spinal angioma.