[3] Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver.

Normally, metabolism of cocaine produces two primarily biologically inactive metabolites—benzoylecgonine and ecgonine methyl ester.

[1] Cocaethylene is largely considered a recreational drug in and of itself, with stimulant, euphoriant, anorectic, sympathomimetic, and local anesthetic properties.

The monoamine neurotransmitters serotonin, norepinephrine, and dopamine play important roles in cocaethylene's action in the brain.

[6] In most users, cocaethylene produces euphoria and has a longer duration of action than cocaine.