He made his professional debut that year with the Low-A Aberdeen IronBirds where he posted a 0–1 record with a 3.00 ERA in nine starts.

[9][10] In 2018, Sedlock split the year between the Gulf Coast Orioles, Aberdeen, and Frederick, combining to go 0–3 with a 5.11 ERA in 36+1⁄3 innings.

Sedlock missed time in 2018 while dealing with the effects of Thoracic outlet syndrome, though he ultimately avoided surgery for the ailment.

[13] He returned to action in 2021, making 24 appearances (16 starts) between Bowie and the Triple-A Norfolk Tides and registering a combined 6-6 record and 4.55 ERA with 100 strikeouts in 93 innings pitched.

[14] In his debut, Sedlock worked three innings of relief against the Boston Red Sox, allowing 5 runs on 6 hits and 1 walk with 3 strikeouts.

[17] On July 10, 2022, Sedlock was traded to the Detroit Tigers in exchange for cash considerations and was assigned to the Triple-A Toledo Mud Hens.