He played in Major League Baseball from 2001 through 2006 for the Baltimore Orioles, Colorado Rockies, and St. Louis Cardinals.

In December 2007, it was announced that he had agreed to a deal to play for the Yokohama Bay Stars of the Nippon Professional Baseball (NPB).

Bigbie made a comeback for the 2010 season, playing for the Edmonton Capitals of the Golden Baseball League.

According to the report, Bigbie admitted to purchasing and using a variety of performance-enhancing substances from Kirk Radomski from 2001 to 2005, including human growth hormone, Deca-Durabolin, Sustanon, testosterone, and anti-estrogen drugs.

Segui reportedly instructed him on "training regimens and the use of creatine, a legal muscle builder, before teaching him about steroids and eventually injecting him with Deca-Durabolin".