[citation needed] Founded at the end of the 16th century, it received the title of "Imperial College" due to the patronage of Empress Maria, daughter of Charles V, Holy Roman Emperor and the wife of Maximilian II, Holy Roman Emperor.
[1] After the expulsion of the Jesuits from Spain (1767), King Charles III re-established the college as the Reales Estudios Superiores de Madrid (1770), a public institution.
[citation needed] In 1835, following the Royal Statute of 1834, the Society of Jesus was suppressed in Spain for the second time, while –more or less simultaneously– the Complutense University moved from Alcalá de Henares to Madrid.
It was renamed Estudios Nacionales, incorporating as a preparatory school with the newly transferred Complutense University (Universidad de Madrid).
In 1999, as part of the decentralization process started with the Spanish Constitution of 1978, the property and management of the Instituto San Isidro was transferred to the Government of the Community of Madrid.