[2] It has educated some of the most influential figures in Puerto Rico such as Fernando Picó, Ruben Berrios and Raúl Juliá.

Colegio San Ignacio de Loyola seeks to offer a superior, Catholic education in the Jesuit tradition to all young men who show aptitude, motivation, and their families' support, and so to serve society and announce the Kingdom of God.

A Family Formation Program offers talks, workshops, and Ignatian spirituality experiences to assist parents in raising adolescents in today's world.

[6] San Ignacio participates in the Puerto Rico High School Athletic Alliance in football, basketball, baseball, bowling, cross country, golf, indoor soccer, swimming, track and field, tennis, and volleyball.

Clubs are sponsored in areas such as school band, debate, United Nations, chess, art, science, medicine, theater, cinema, mathematics, technology, ECO-Ignatian, business, investors, robotics, photography, French, history, and engineering.