The building principal was Christopher Robilotti until the 2020–2021 school year when Thomas Kachadurian was promoted.

Colonie High School offers Advanced Placement (AP) courses in numerous disciplines.

Colonie also has a large technology department, where students can take all of the courses in the Project Lead the Way engineering sequence.

Also, the school offers credits from SUNY Albany, RIT and College of St. Rose.

Three foreign languages are taught at the school, including Spanish, French and Italian.