SH 227's southern terminus is at U.S. Route 50 Business (US 50 Bus.)

in Salt Creek, and the northern terminus is at SH 96 in Pueblo.

The highway begins at an interchange with US 50 Business as a continuation of Roselawn Road.

The route makes a left onto South Joplin Avenue, intersecting a BNSF railroad.

Media related to Colorado State Highway 227 at Wikimedia Commons