The region has three cities and seven towns as well as the Fort Sill military installation and Wichita Mountains Wildlife Refuge.

The landscape of the county is typical of the Great Plains with flat topography and gently rolling hills, while the areas in the north are marked by the Wichita Mountains.

The governance of the county is led by a three commission board, which are elected in four year staggered terms.

The county is served by several school districts and Cameron University in education as well as three hospitals for health care.

[7] In 1874, the Red River War broke out in the region when the Comanche, Kiowa and Southern Cheyenne left their Indian Territory reservation.

Attrition and skirmishes by the US Army finally forced the return of the tribes back to Indian Territory in June 1875.

[7] In 1891, the United States Congress appointed a commission to meet with the tribal leaders and come to an agreement allowing white settlement in the region.

Years of controversy and legal maneuvering ensued before President William McKinley issued a proclamation on July 4, 1901, that gave the federal government control over 2,000,000 acres (8,100 km2) of surplus Indian land.

[13] Comanche County lies in an area that is typical of the Great Plains with prairie, few trees, and generally flat topography with gently rolling hills.

[15] The area consists mostly of Permian Post Oak Conglomerate limestone on the northern sections of the county.

In the south sections of the county, Permian Garber Sandstone is commonly found with some Hennessey Group shale.

Several towns dot the county including: Fletcher, Sterling in the northeast, Medicine Park in the north central region, Indiahoma in the west, Geronimo in the southeast, and Chattanooga and Faxon in the southern regions of the county.

[19] Protected areas in Comanche County include the 59,020 acre Wichita Mountains Wildlife Refuge.

[21] Typically in late April through early June, Comanche County is prone to severe weather which can include tornadoes.

[38] At the federal level, Lawton lies in Oklahoma 4th Congressional district, represented by Tom Cole.

[42] Comanche County's economy is primarily centered on government, manufacturing and retail trade industries.

Radio stations in Lawton include, two AM Stations KXCA 1050 and KKRX 1380 as well as several FM stations including, NPR affiliate KCCU 89.3, KZCD 94.1, KMGZ 95.3, KJMZ 97.9, KBZQ 99.5, KLAW 101.3 and KVRW 107.3[45] Comanche County is located in the Wichita Falls and Lawton Media Market which encompasses 154,450 households with a television, making it the 149th largest in the nation according to Nelson Media Research in 2009–2010.

[47] KSWO-TV channel 7, an ABC affiliate, is the only broadcast television station in the area that provides local news.

[48] All other major stations including, KFDX-TV 3 (NBC), KAUZ-TV (CBS), and KJTL-TV (Fox) are based in Wichita Falls.

Other major thoroughfares include US Highway 277 and 281, which parallels the H. E. Bailey Turnpike to Wichita Falls to the south and leads to regional towns of Anadarko and Chickasha, respectively, to the north.

LATS main terminal is located near the Lawton Public Library and provides five major routes throughout the city.

[49] Intercity transit is provided by Greyhound Lines, with buses traveling towards Oklahoma City and Dallas.

[51] By air, Comanche County is served by the Lawton-Fort Sill Regional Airport (LAW, KLAW).

At present, it offers daily American Eagle flights to Dallas/Fort Worth International Airport and is also used for military transport.

[57] Other public school districts in the region include, Bishop Chattanooga, Fletcher, Flower Mound, Geronimo, Indiahoma, and Sterling.

Cameron is the largest four year, state-funded university, in southwest Oklahoma, offering more than 50 degree programs in areas of Business, Education, Liberal Arts and Science and Technology.

Great Plains provides occupational education, training, and development opportunities to area residents.

[68] Notable residents include country singers: Bryan White,[69] Kelly Willis,[70] and Leon Russell,[71] Grammy nominated jazz trombonist Conrad Herwig,[72] and Flaming Lips drummer Steven Drozd.

Other notable residents include: World War II Comanche Code Talker Charles Chibitty,[78] World War II Nurse and POW Col. Rosemary Hogan,[79] Academy Award winning actress Joan Crawford,[80] World War II ace Robert S. Johnson,[81] three time NBA champion Stacey King,[82] former NBA All-Star Michael Ray Richardson,[83] Miss America 2007 Lauren Nelson,[84] infamous University of Oklahoma quarterback Charles Thompson,[85] NFL Pro Bowlers Will Shields[86] and Jammal Brown[87] Quanah Parker built his final residence in the town of Cache, Comanche County.