She was born to count Wilhelm Moritz Heinrich von Ludolf, Ambassador of Naples in Constantinople, and Catherine Chabert, and married the ambassador of France, François-Emmanuel Guignard, comte de Saint-Priest, in October 1774.
During the French Revolution, the couple left for Sweden, where they participated in high society.
In the summer of 1794, they were banned from the Swedish royal court at Drottningholm Palace, as it had become known that they were given an allowance from Catherine the Great and assumed to be dangerous Russian spies.
In the spring of 1796, the movement of Russian troops along the Finnish border gave rise to suspicions in Sweden that Russia was preparing war because of the discontent of Catherine the Great that Gustav IV Adolf of Sweden had been engaged to Duchess Louise Charlotte of Mecklenburg-Schwerin instead of Grand Duchess Alexandra Pavlovna of Russia.
The Swedish government of Gustaf Adolf Reuterholm tried to negotiate with the Russian ambassador to Stockholm, Andrei Budberg, but without success.