Duchess Louise Charlotte of Mecklenburg-Schwerin (19 November 1779 – 4 January 1801) was the maternal grandmother of Prince Albert, husband of Queen Victoria of the United Kingdom.

Her mother was Princess Louise of Saxe-Gotha-Altenburg; her sister Charlotte of Mecklenburg-Schwerin (1784–1840) married King Christian VIII of Denmark.

The engagement was arranged by Gustaf Adolf Reuterholm, the de facto regent of Sweden, who wished to keep his influence after the monarch was declared of legal majority by having a queen indebted to him for her position.

Empress Catherine the Great, however, wished her granddaughter Grand Duchess Alexandra Pavlovna of Russia to be Queen of Sweden, and displayed dislike of the engagement.

In Ludwigslust on 21 October 1797 Louise Charlotte married Augustus, Hereditary Prince of Saxe-Gotha-Altenburg, a second cousin on her mother's side.