The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus).

The two amino acid cysteine residues in contryphans are linked by a disulfide bond.

In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation.

"[3] Contryphan family members include: where the sequence abbreviations stand for: and the remainder of the letters refer to the standard one letter abbreviations for amino acids.

The venom of cone snails cause paralysis of their fish prey.