Santa Maria delle Grazie ("Holy Mary of Grace") is a church and Dominican convent in Milan, northern Italy, and a UNESCO World Heritage Site.

Duke of Milan Francesco I Sforza ordered the construction of a Dominican convent and church at the site of a prior chapel dedicated to the Marian devotion of St Mary of the Graces.

Previously distorted by attempts at restoration carried out over the centuries, Leonardo’s original painting has now emerged as a result of the work begun in 1978 and completed in 1999.

This involved addressing complex problems as regards not only the painting itself but also the environment of the refectory in order to protect the work from the dust, fumes and humidity identified as the primary causes of its constant deterioration.

Nowadays the Sacrestia vecchia, or the Old Sacristy, designed and constructed by Donato Bramante, is the seat of a Dominican Cultural Centre (Centro Culturale alle Grazie), in which the brethren organize and host conferences on various themes pertaining to spirituality, philosophy, art, literature and sociology, in addition to musical concerts and artistic exhibitions.