The centralized, symmetric plan, surmounted by a tall dome, distinguishes this Renaissance church, from the more common elongated basilica or Latin-cross designs.
Another Todi sanctuary church, also with a symmetric layout, is the Tempio del Santissimo Crocifisso on the eastern end of town.
[6] In 1531, the Compagnia di Santa Maria della Consolazione who managed the site ceded the church to Hieronymite monks from a community at Fiesole.
Payments were made to Giacomo Vignola in 1565; to Galeazzo Alessi in 1567; and William of Portugal in 1584; all presumably related to the design of the dome.
[7] The church is built in a Greek cross plan: three apses are polygonal and the one on the north side is semicircular.