2006 Copa Sudamericana

Pachuca won their first title in history after defeating Colo-Colo tying 1–1 in the first leg in Mexico, and winning 2–1 in Chile.

Pachuca only lost one game in the tournament, against Colombian Deportes Tolima 2–1 in their debut.

This was the second time a Mexican club reached the final, after UNAM lost the 2005 edition to Boca Juniors.

Also, this was the first (and to date only) time a Mexican (or CONCACAF) representative won the Copa Sudamericana or any CONMEBOL-sanctioned tournament.

It was played by the ten winners from the first round, plus River Plate, Boca Juniors, Gimnasia y Esgrima, Alajuelense, Toluca and Pachuca.