The story follows three high school girls who were genetically engineered to be impervious to radioactivity and sent to Tokyo after the city was contaminated by a nuclear accident.

Due to genetic engineering, the Coppelions are immune to radiation while also possessing special skills.

Coppelion, written and illustrated by Tomonori Inoue, was serialized in Kodansha's Weekly Young Magazine from June 9, 2008,[4] to May 7, 2012.

[7][8] The manga's last chapter was drawn live in a free seminar at the Vantan Game Academy in Osaka, on November 22, 2015.

[9] Kodansha collected its chapters in twenty-six tankōbon volumes, released from October 6, 2008, to April 6, 2016.