The Cordillera Domeyko is a mountain range of the Andes located in northern Chile, west of Salar de Atacama.

It runs north-south for approximately 600 km,[1] parallel to the main chain.

The mountain range marks the eastern border of the flat parts of Atacama Desert.

The western border of Cordillera Domeyko is characterized by a inland cliffs and a sharp topographic transition known as El Bordo Escarpment.

[2] El Bordo Escarpment contain the main rock outcrops of the Purilactis Group, which make up much of the mountain range.