Coronary perfusion pressure

If pressures are too low in the coronary vasculature, then the myocardium risks ischemia (restricted blood flow) with subsequent myocardial infarction or cardiogenic shock.

That is, when the ventricular myocardium is working, it extracts oxygen from the coronary blood and produces adenosine as a byproduct of ATP use.

[1] The concept of CPP, while relevant to overall cardiovascular physiology, is acutely important in cardiac arrest care.

First, the compressions circulate blood to the brain and other tissues which helps reduce their ischemia and attenuates later post-cardiac arrest syndrome.

[3] During cardiac arrest, CPP is one of the most important variables associated with the likelihood of return of spontaneous circulation (ROSC), the restoration of a pulse.

[4] Epinephrine, administered as part of ACLS for cardiac arrest care seems to increase CPP due to its combined effects of inotropy and vasoconstriction.

However once the vasodilatory capacity is maximized, the coronary arteries become solely dependent on high enough CPP to perfuse past the atherosclerotic lesion.

[6] Heart failure, both with and without preserved ejection fraction, though through different mechanisms, result in an increase in left ventricular end-diastolic pressure (LVEDP).