Corpus Christi Memorial Hospital originally opened in May 1944 and was run by Nueces County.

In May 2017, with construction underway for the Shoreline expansion and the HPG Clinic opened in January, services began shutting down at Memorial.

The level II trauma designation was transferred to Spohn Shoreline on May 1, 2017,[1] and Memorial stopped admitting patients to wards.

The 10-bed emergency department remained open, though all medical patients requiring admission were transferred to other facilities.

In August 2017, the hospital was damaged by water from Hurricane Harvey, temporarily shutting down the emergency department and behavioral health services that were still open at the time.