Dallas Methodist Hospital began caring for patients on December 24, 1927, and officially opened as a 100-bed institution on January 27, 1928.

A three-story student nurse's residence was built near the hospital in 1951, and the Martin and Charlotte Weiss Educational Building, which provided classroom space for nursing education and a large auditorium for community programming, opened in 1966.

Methodist Dallas launched the six-story, 248,000-square-foot Charles A. Sammons Trauma and Critical Care Tower in July 2014.

[2][3][4] On October 22, 2022, an armed assailant opened fire in the hospital's maternity ward, killing a nurse and a case worker.

[5][6][7] The suspect arrested, 30-year-old Nestor Hernandez from North Dallas, was on parole for aggravated robbery at the time of the shooting.