Corynanthine, also known as rauhimbine, is an alkaloid found in the Rauvolfia and Corynanthe (including Pausinystalia) genera of plants.

[1][2] It is one of the two diastereoisomers of yohimbine, the other being rauwolscine.

Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist with approximately 10-fold selectivity for the former site over the latter.

[3][4] As a result, corynanthine is not a stimulant (or an aphrodisiac for that matter), but a depressant, and likely plays a role in the antihypertensive properties of Rauvolfia extracts.

Like yohimbine and rauwolscine, corynanthine has also been shown to possess some activity at serotonin receptors.