From here, it heads east on Dr. Martin Luther King Jr. Boulevard for about half a mile, where it intersects with SR 717.

At Twenty Mile Bend, CR 880 terminates at Southern Boulevard (which carries SR 80, US 98, and US 441).

[3] Just south of its intersection with SR 80/US 98/US 441 in Twenty Mile Bend, CR 880 crosses the C-51 canal on a historic truss bridge.

The route from Belle Glade to Palm Beach was complete in 1923 as part of SR 80 (which was designated SR 25 prior to the 1945 Florida State Road renumbering).

[6] The current four-lane alignment of SR 80 and US 441 to the north (designated as the Kenneth C. Mock Memorial Highway) was built in 1989.