The highway extends 39 miles (63 km) from the Commodore Barry Bridge crossing the Delaware River at Chester at the Pennsylvania state line and Logan Township, to U.S. Route 206 (US 206) in Hammonton.

The route heads southeast on two-lane undivided Main Street into residential and commercial areas.

Upon intersecting CR 659, the route turns north onto Malaga Road and enters wooded areas, crossing the Four Mile River into Winslow Township, Camden County and passing over the Atlantic City Expressway.

[1][3] A short distance later, the route turns east onto Pump Branch Road and continues through farmland and residential subdivisions, intersecting CR 718.

CR 536 intersects US 30 and forms a brief concurrency with that route on four-lane undivided White Horse Pike before heading northeast onto two-lane Pennington Avenue.

The route passes an agricultural clearing before crossing back into the forests and coming into Hammonton in Atlantic County, where CR 536 ends at US 206.