The highway extends 14.76 miles (23.75 km) from Lakehurst Road (CR 530) in Pemberton Township to West Park Street in Bordentown.
The route runs to the west of Deborah Heart and Lung Center before entering wooded areas with residences located along the east side of the road as it enters the grounds of the Fort Dix entity of Joint Base McGuire–Dix–Lakehurst (JB MDL) within New Hanover Township and becomes Texas Avenue.
Along this stretch, the road runs between Fort Dix buildings to the west and McGuire Air Force Base to the east.
Here, CR 545 intersects Bordentown Road, which provides access to Route 68 a short distance to the west, and it makes a turn to the north into more residential areas.
After crossing over Conrail Shared Assets Operations' Robbinsville Industrial Track railroad line, the route reaches its northern terminus at the CR 662 (Park Street) intersection.