The eastern end of the highway sustained extensive damage in 2012 when an inlet opened between Barnegat Bay and the Atlantic Ocean during Hurricane Sandy, scouring away the road east of the Mantoloking Bridge.

The route crosses US 130/US 206 in commercial areas before continuing into Bordentown Township and passing a mix of farm fields, businesses, and residential neighborhoods.

The road enters Chesterfield Township, turning southeast and crossing over the New Jersey Turnpike (I-95) before reaching a junction with CR 672.

The route turns southeast onto Jacobstown-Chesterfield Road at the CR 664 intersection and continues through areas of farmland, woodland, and residences as it crosses into North Hanover Township.

After intersecting CR 616, the route heads east onto Main Street and passes through the commercial downtown of New Egypt before turning northeast near more homes.

From here, the route enters forested areas of the Pine Barrens with some residences, crossing into Jackson Township at the CR 640 intersection.

In this area, the routes turn east onto Central Avenue and passes more homes before crossing Lake Carasaljo and coming to an intersection with US 9.

After crossing the Southern Secondary railroad line operated by the Delaware and Raritan River Railroad, the road continues through commercial, residential, forested and then commercial areas again prior to reaching the CR 623 junction at ShoreTown Ballpark, the home ballpark of the Jersey Shore BlueClaws baseball team.

CR 528 from Jacobstown to Lakewood was signed as part of the Camp Dix Way, an auto trail stretching from Camden to Seaside Heights.