The routes turn northwest through residential and commercial areas along with some marshland from the adjacent Barnegat Bay to the east, with alternating segments of median and center left-turn lane.

The route widens into a divided highway as it passes between the Ocean County Mall to the north and the Seacourt Pavilion shopping center to the south and intersects CR 549 at an at-grade cloverleaf interchange.

The route runs through forested areas of the Pine Barrens with intermittent residential development for several miles, eventually turning north and coming to the junction with CR 528 in the community of Cassville.

The route crosses back into Millstone Township and heads into areas of farmland and woodland, turning northwest at the CR 1 junction.

The route passes more residences, the Stockton Street Historic District, before crossing back into East Windsor Township and intersecting US 130.

The route narrows to two lanes and turns north at this point, passing a mix of homes and businesses as it reaches the CR 615 junction.

Past the terminus of Route 64, CR 571 continues northwest on two-lane undivided Washington Road, passing through wooded residential areas before intersecting US 1 at the modified Penns Neck Circle.

At this point, CR 571 runs through the heart of the Princeton University campus, reaching its northern terminus at Route 27 (Nassau Street).

[10] In the summer of 2012, NJDOT installed barriers at the Penns Neck Circle to prevent "left-turning" traffic from US 1 in either direction onto CR 571.

[11] In conjunction with other blockades of nearby intersections, this 12-week pilot program was meant to improve traffic flows along the congested US 1.

[13] The various alternatives would have begun near the northern terminus of Route 64 at a new grade-separated interchange to provide access to the Princeton Junction Station and the existing Washington Road, run north of Penns Neck through the David Sarnoff Research, cross US 1 at a new grade-separated interchange, and return to the existing alignment south of the Millstone River.