When designated in 1930, NY 175 was on a rural stretch of highway connecting Marcellus to Onondaga, and brought about an increase in population and development along its route.

The highway heads towards the northeast as Lee Mulroy Road, passing by farmlands and fields as well as several residences.

The southern terminus of unsigned County Route 73 (CR 73, named South Street Road) is also at the intersection with NY 174.

In downtown Marcellus, the terrain is flat, with residential homes and commercial businesses surrounding the road.

At the intersection with Frank Gay Road (CR 243), NY 175 passes a golf course and country club.

[4] After leaving NY 173 and the Seneca Turnpike, the highway heads to the northeast through the town of Onondaga as South Avenue.

[4] It intersects a number of city streets as it heads to the northeast, traversing several mixed-use blocks before crossing Onondaga Creek, a north–south waterway that passes through most of Syracuse.

Genesee Road was approved by the state legislature in 1794, and construction began in sections from Utica to Canandaigua.

[2][3][16] The configuration of NY 175 remained unchanged until the early 1960s when the route was re-extended westward over the New Seneca Turnpike to its original terminus in Skaneateles.

[18][19] Ownership and maintenance of the former alignment of NY 175 on the New Seneca Turnpike was eventually transferred to Onondaga County, which designated the highway as CR 41.

Additionally, the modern alignment of NY 175 on Lee Mulroy Road is maintained by Onondaga County and co-designated as CR 73.