At the east end of the overlap, it splits off follows a more southeasterly routing through the village of Manlius to Cazenovia.

At East Avenue, a local street just west of Nottingham Senior High School, a center lane begins, enabling left turns from both directions.

The route passes north of the school and St. Mary's Cemetery and south of LeMoyne College before exiting the city limits.

[4] At this point, maintenance of the route shifts from Syracuse to the New York State Department of Transportation (NYSDOT).

East of the interchange, Genesee Street widens to six lanes (three in each direction) as it heads along a commercial strip anchored by a large plaza featuring a Wegmans Food Markets store.

Past this point, the amount of development along the highway increases as it approaches an intersection with NY 257 just inside of the Manlius village limits.

NY 92 follows Limestone Creek southeastward through the towns of Manlius and Pompey to the Madison County line, where the creek turns south to run through Pompey Hollow, an area of flatlands situated on the Onondaga County side of the line.

Most of NY 92 in Madison County passes through rural, undeveloped areas; however, the section just north of its intersection with US 20 runs along Cazenovia Lake and serves several lakeside homes.

[4] NY 92 was assigned as part of the 1930 renumbering of state highways in New York to a northwest–southeast roadway connecting Fayetteville to Cazenovia.