Minnesota State Highway 112 (MN 112) was a 15.012-mile-long (24.159 km) highway in south-central Minnesota, which ran from its interchange with U.S. Highway 169 in the city of Le Sueur and continued south and then east to its eastern terminus at its intersection with State Highway 99 in Lexington Township near the city of Le Center.

Highway 112 changed direction to east–west in Ottawa Township and continued as east–west to its eastern terminus near the city limits of Le Center.

[3] A section of Main Street (formerly Highway 112) in the city of Le Sueur was originally part of old U.S. Highway 169 until the new U.S. 169 bypass was constructed west of town in the early 1960s.

[3] It was announced on April 19, 2019 that the highway was handed over to Le Sueur County.

[4] It was renamed to Le Sueur County Road 22 and reconstructed.