CoxHealth started on Thanksgiving Day, in 1906, when Ellen Burge, the widow of a prominent Springfield lawyer, donated her frame duplex on Jefferson Avenue to be used as a Methodist hospital.

The Burge Hospital grew due to the great need for expert healthcare in Southwest Missouri.

Former Presidents include Neil Wortley, Charlie Edwards, Larry Walls, and Robert Bezanson.

Cox Medical Center South is the largest facility and main campus operated by CoxHealth.

The Jared Neuoro Science Center and The Dee Ann White Women's and Children's hospital are featured in the newest 10 story tower on the campus.

[6] A Ronald McDonald House is located on the Cox South campus to provide a low cost and friendly living area for those with children in the hospital.

Cox Health Plans is an affiliate of CoxHealth that provides insurance for nearly 45,000 members across Missouri and throughout the nation.

Starting in 1995, Cox HealthPlans is composed of teams in Medical Management, Claims Processing, Member Services, Finance, Underwriting, Information Technology, and Marketing.

Cox HealthPlans received the 2011 Trizetto IHM Power Award in the category of Operational Excellence.

CoxHealth Monett features an emergency department, 25-bed inpatient unit, radiology and laboratory, and is attached to the outpatient clinic.

Cox Barton County-is a 25-bed critical access hospital operating in Lamar, Missouri, and joined the system in 2018.

[citation needed] CoxHealth also offers multiple urgent care centers including one in Springfield that is operated 24 hours per day.